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PTGDS protein levels

PRKAG2 · rs73158188

Where this position leads

Condition: Celiac Disease

rs73158188 Condition: Celiac Disease Celiac Disease Condition rs73158188 rs73158188 PRKAG2

What the study found

Who was studied 47,745 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.043 higher (95% confidence interval 0.031-0.055); p = 3 × 10−14.

How common The T allele had a frequency of about 29% in the people studied.

Where it sits Chromosome 7, band 7q36.1 — in an intron of PRKAG2.

What each result means

C/C No copy of the version the research linked to PTGDS protein levels. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to PTGDS protein levels. That is a smaller link than two copies.
T/T Two copies of the version the research linked to PTGDS protein levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs73158188

What is rs73158188?

rs73158188 is a single position in the genome, in or near the PRKAG2 gene. Published research associates it with ptgds protein levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs73158188 linked to?

On MyGeneLog this position is linked to Celiac Disease. The research behind each link, and its sources, are set out on that condition page.

Does having rs73158188 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs73158188 come from?

GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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PTGDS protein levels (rs73158188). MyGeneLog™. https://www.mygenelog.com/variants/rs73158188

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