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Sex hormone-binding globulin levels

CUX2 · rs7314285

What the study found

Who was studied 180,726 European ancestry men.

The effect Each copy of the G allele shifted the measure 0.0301 higher (95% confidence interval 0.025-0.035); p = 2 × 10−41.

How common The G allele had a frequency of about 7% in the people studied.

Where it sits Chromosome 12, band 12q24.11 — in an intron of CUX2.

What each result means

G/G Two copies of the version the research linked to Sex hormone-binding globulin levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
G/T One copy of the version the research linked to Sex hormone-binding globulin levels. That is a smaller link than two copies.
T/T No copy of the version the research linked to Sex hormone-binding globulin levels. This is the starting point the study compared everyone against.
Source

Questions about rs7314285

What is rs7314285?

rs7314285 is a single position in the genome, in or near the CUX2 gene. Published research associates it with sex hormone-binding globulin levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs7314285 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7314285 come from?

GWAS Catalog, Nature medicine 2020, PMID:32042192. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Sex hormone-binding globulin levels (rs7314285). MyGeneLog™. https://www.mygenelog.com/variants/rs7314285

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