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Its strongest genetic-study result is p = 10−11, with 3 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 21,816 African ancestry, admixed American, East Asian ancestry, European ancestry, South Asian ancestry, Greater Middle Eastern cases, 2,895,812 African ancestry, admixed American, East Asian ancestry, European ancestry, South Asian ancestry, Greater Middle Eastern controls.
The effect
Each copy of the C allele shifted the measure 0.136 higher (95% confidence interval 0.096-0.176); p = 2 × 10−11.
How common The C allele had a frequency of about 8% in the people studied.
Where it sits Chromosome 20, band 20p13 — between genes, 0 kb from LINC01730.
How common each version is
CT
Japanese ToMMo
T 100.0%
World gnomAD
C 6.1% · T 93.9%
World 1000 Genomes
C 3.3% · T 96.7%
World TOPMed
C 5.9% · T 94.0%
The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study. No Korean figure for this position yet.
What each result means
C/CTwo copies of the version the research linked to Thyroid cancer. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Thyroid cancer. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Thyroid cancer. This is the starting point the study compared everyone against.
Nature genetics · 2026 · PMID 41644669 · open access
Questions about rs73082522
What is rs73082522?
rs73082522 is a single position in the genome, in or near the near CDC25B gene. Published research associates it with thyroid cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs73082522 linked to?
On MyGeneLog this position is linked to Thyroid Cancer. The research behind each link, and its sources, are set out on that condition page.
Does having rs73082522 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs73082522 come from?
GWAS Catalog, GWAS Catalog n.d., PMID:41644669. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Thyroid cancer (rs73082522). MyGeneLog™. https://www.mygenelog.com/variants/rs73082522