Gene Knowledge Graph
UTC
Standard

COVID-19 (critical illness vs population)

LZTFL1 · rs73064425

Where this position leads

Condition: Abacavir Hypersensitivity (HLA-B*57:01)

rs73064425 Condition: Abacavir Hypersensitivity (HLA-B*57:01) Abacavir Hypersensitivity (HLA-B*57:01) Condition rs73064425 rs73064425 LZTFL1

What the study found

Who was studied 1,676 European ancestry cases, 8,380 European ancestry controls; replicated in 2,415 European, South Asian and Hispanic or Latin American ancestry cases, 477,741 European, South Asian and Hispanic or Latin American ancestry controls, 1,128 European ancestry cases, 679,531 European ancestry controls.

The effect Each copy of the T allele carried 1.70 times the odds of COVID-19 (critical illness vs population); p = 2 × 10−28.

Where it sits Chromosome 3, band 3p21.31 — in an intron of LZTFL1.

What each result means

C/C No copy of the version the research linked to COVID-19 (critical illness vs population). This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to COVID-19 (critical illness vs population). That is a smaller link than two copies.
T/T Two copies of the version the research linked to COVID-19 (critical illness vs population). That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Genetic mechanisms of critical illness in COVID-19
Pairo-Castineira E, Clohisey S, Klaric L, Bretherick AD, Rawlik K, Pasko D, Walker S, Parkinson N, Fourman MH, Russell CD, Furniss J, Richmond A
and 54 more — show all
Gountouna E, Wrobel N, Harrison D, Wang B, Wu Y, Meynert A, Griffiths F, Oosthuyzen W, Kousathanas A, Moutsianas L, Yang Z, Zhai R, Zheng C, Grimes G, Beale R, Millar J, Shih B, Keating S, Zechner M, Haley C, Porteous DJ, Hayward C, Yang J, Knight J, Summers C, Shankar-Hari M, Klenerman P, Turtle L, Ho A, Moore SC, Hinds C, Horby P, Nichol A, Maslove D, Ling L, McAuley D, Montgomery H, Walsh T, Pereira AC, Renieri A, Shen X, Ponting CP, Fawkes A, Tenesa A, Caulfield M, Scott R, Rowan K, Murphy L, Openshaw PJM, Semple MG, Law A, Vitart V, Wilson JF, Baillie JK
GenOMICC Investigators · ISARIC4C Investigators · COVID-19 Human Genetics Initiative · 23andMe Investigators · BRACOVID Investigators · Gen-COVID Investigators
Nature · 2021 · PMID 33307546

Questions about rs73064425

What is rs73064425?

rs73064425 is a single position in the genome, in or near the LZTFL1 gene. Published research associates it with covid-19 (critical illness vs population). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs73064425 linked to?

On MyGeneLog this position is linked to Abacavir Hypersensitivity (HLA-B*57:01). The research behind each link, and its sources, are set out on that condition page.

Does having rs73064425 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs73064425 come from?

GWAS Catalog, Nature 2020, PMID:33307546. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

COVID-19 (critical illness vs population) (rs73064425). MyGeneLog™. https://www.mygenelog.com/variants/rs73064425

← See all variants