PEG-asparaginase hypersensitivity without enzyme activity in childhood acute lymphoblastic leukaemia
CNOT3 · rs73062673
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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 59 European ancestry cases, 772 European ancestry controls.
The effect
Each copy of the C allele carried 3.73 times the odds of PEG-asparaginase hypersensitivity without enzyme activity in childhood acute lymphoblastic leukaemia (95% confidence interval 2.33-5.98); p = 5 × 10−8.
How common The C allele had a frequency of about 9% in the people studied.
Where it sits Chromosome 19, band 19q13.42 — in an intron of CNOT3.
What each result means
C/CTwo copies of the version the research linked to PEG-asparaginase hypersensitivity without enzyme activity in childhood acute lymphoblastic leukaemia. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to PEG-asparaginase hypersensitivity without enzyme activity in childhood acute lymphoblastic leukaemia. That is a smaller link than two copies.
T/TNo copy of the version the research linked to PEG-asparaginase hypersensitivity without enzyme activity in childhood acute lymphoblastic leukaemia. This is the starting point the study compared everyone against.
British journal of haematology · 2019 · PMID 30450575
Questions about rs73062673
What is rs73062673?
rs73062673 is a single position in the genome, in or near the CNOT3 gene. Published research associates it with peg-asparaginase hypersensitivity without enzyme activity in childhood acute lymphoblastic leukaemia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs73062673 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs73062673 come from?
GWAS Catalog, Br J Haematol 2018, PMID:30450575. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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PEG-asparaginase hypersensitivity without enzyme activity in childhood acute lymphoblastic leukaemia (rs73062673). MyGeneLog™. https://www.mygenelog.com/variants/rs73062673