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Asthma (moderate or severe)

RPS26 · rs7305461

Where this position leads

Condition: Asthma

rs7305461 Condition: Asthma Asthma Condition rs7305461 rs7305461 RPS26

What the study found

Who was studied 5,135 European ancestry cases, 25,675 European ancestry controls; replicated in 5,414 European ancestry cases, 21,471 European ancestry controls.

The effect Each copy of the A allele carried 1.10 times the odds of Asthma (moderate or severe) (95% confidence interval 1.06-1.14); p = 1 × 10−9.

How common The A allele had a frequency of about 45% in the people studied.

Where it sits Chromosome 12, band 12q13.2 — between genes, 11.4 kb from RPS26.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Asthma (moderate or severe) compared to the general population.
A/C Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Asthma (moderate or severe).
C/C Published research associates this genotype with typical/baseline likelihood of Asthma (moderate or severe) — no copies of the reported risk allele.
Source
Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study
Shrine N, Portelli MA, John C, Soler Artigas M, Bennett N, Hall R, Lewis J, Henry AP, Billington CK, Ahmad A, Packer RJ, Shaw D
and 31 more — show all
Pogson ZEK, Fogarty A, McKeever TM, Singapuri A, Heaney LG, Mansur AH, Chaudhuri R, Thomson NC, Holloway JW, Lockett GA, Howarth PH, Djukanovic R, Hankinson J, Niven R, Simpson A, Chung KF, Sterk PJ, Blakey JD, Adcock IM, Hu S, Guo Y, Obeidat M, Sin DD, van den Berge M, Nickle DC, Bossé Y, Tobin MD, Hall IP, Brightling CE, Wain LV, Sayers I
The Lancet. Respiratory medicine · 2019 · PMID 30552067 · open access

Questions about rs7305461

What is rs7305461?

rs7305461 is a single position in the genome, in or near the RPS26 gene. Published research associates it with asthma (moderate or severe). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs7305461 linked to?

On MyGeneLog this position is linked to Asthma. The research behind each link, and its sources, are set out on that condition page.

Does having rs7305461 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7305461 come from?

GWAS Catalog, Lancet Respir Med 2018, PMID:30552067. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Asthma (moderate or severe) (rs7305461). MyGeneLog™. https://www.mygenelog.com/variants/rs7305461

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