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Childhood ear infection

PLG · rs73015965

Where this position leads

Condition: Tonsillectomy (Throat Infection Susceptibility)

What the study found

Who was studied 46,936 European ancestry cases, 74,874 European ancestry controls.

The effect Each copy of the G allele carried 1.43 times the odds of Childhood ear infection (95% confidence interval 1.34-1.53); p = 4 × 10⁻⁸.

How common The G allele had a frequency of about 1% in the people studied.

Where it sits Chromosome 6, band 6q26 — a missense change in PLG.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Childhood ear infection — no copies of the reported risk allele.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Childhood ear infection.

G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Childhood ear infection compared to the general population.

Source

Genome-wide association and HLA region fine-mapping studies identify susceptibility loci for multiple common infections

Tian C, Hromatka BS, Kiefer AK, Eriksson N, Noble SM, Tung JY, Hinds DA

Nature communications · 2017 · PMID 28928442 · open access

Questions about rs73015965

What is rs73015965?

rs73015965 is a single position in the genome, in or near the PLG gene. Published research associates it with childhood ear infection. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs73015965 linked to?

On MyGeneLog this position is linked to Tonsillectomy (Throat Infection Susceptibility). The research behind each link, and its sources, are set out on that condition page.

Does having rs73015965 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs73015965 come from?

GWAS Catalog, Nat Commun 2017, PMID:28928442. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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