CYP19A1 · rs730154
Where this position leads
Condition: Height
What the study found
Who was studied 160,330 Japanese ancestry individuals; replicated in 63,224 Japanese ancestry individuals.
The effect Each copy of the C allele shifted the measure 0.293 higher (95% confidence interval 0.21-0.37); p = 5 × 10−13.
Where it sits Chromosome 15, band 15q21.2 — in an intron of CYP19A1.
2026-01-28 · Namba S, et al., Nature 2026, PMID:41606330
A cross-population compendium of gene-environment interactions
An atlas of gene-environment interactions — where a variant's effect size differs by age, sex or lifestyle — built from 440,210 people of European and Japanese ancestry and replicated in 539,794 more from diverse populations. Decomposing the contributions of age, sex and lifestyle exposed the aetiology of these interactions, including reverse causality from disease-driven changes in diet, and showed that they affect polygenic prediction accuracy and how well scores transfer across populations. Omics-level analyses found sex-discordant genetic effects in lipid metabolism, which the authors connect to failures of genetically supported drug trials. The variant that dominates this catalogue's overlap with the study is rs671 in ALDH2 — the alcohol flush variant — whose effects on liver enzymes (AST, ALT), HDL cholesterol and red-cell indices differ by sex, ever-drinking and smoking; also on this site from the study: rs145954970 (SLC22A11, uric acid, gout), rs11066015 (ACAD10, red-cell count by drinking), rs730154 (CYP19A1, height by sex) and rs35747824 (PDILT, creatinine by age). PMID:41606330.
rs730154 is a single position in the genome, in or near the CYP19A1 gene. Published research associates it with height x sex interaction. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Height. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nature 2026, PMID:41606330. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Height x sex interaction (rs730154). MyGeneLog™. https://www.mygenelog.com/variants/rs730154