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Medication use (HMG CoA reductase inhibitors)

SMARCA4 · rs73013176

Where this position leads

Condition: Medication Use as a Genetic Trait

rs73013176 Condition: Medication Use as a Genetic Trait Medication Use as a Genetic Trait Condition rs73013176 rs73013176 SMARCA4

What the study found

Who was studied 73,475 European ancestry cases, 216,910 European ancestry controls.

The effect Each copy of the C allele shifted the measure 0.166 lower (95% confidence interval 0.11-0.22); p = 1 × 10−9.

How common The C allele had a frequency of about 1% in the people studied.

Where it sits Chromosome 19, band 19p13.2 — in an intron of SMARCA4.

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Medication use (HMG CoA reductase inhibitors) compared to the general population.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Medication use (HMG CoA reductase inhibitors).
T/T Published research associates this genotype with typical/baseline likelihood of Medication use (HMG CoA reductase inhibitors) — no copies of the reported risk allele.
Source

Questions about rs73013176

What is rs73013176?

rs73013176 is a single position in the genome, in or near the SMARCA4 gene. Published research associates it with medication use (hmg coa reductase inhibitors). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs73013176 linked to?

On MyGeneLog this position is linked to Medication Use as a Genetic Trait. The research behind each link, and its sources, are set out on that condition page.

Does having rs73013176 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs73013176 come from?

GWAS Catalog, Nat Commun 2019, PMID:31015401. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Medication use (HMG CoA reductase inhibitors) (rs73013176). MyGeneLog™. https://www.mygenelog.com/variants/rs73013176

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