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Ovarian cancer-related tumor marker CA 125 levels

GAL3ST2 · rs73011950

Where this position leads

Condition: Ovarian Cancer

rs73011950 Condition: Ovarian Cancer Ovarian Cancer Condition rs73011950 rs73011950 GAL3ST2

What the study found

Who was studied 21,758 European ancestry individuals; replicated in 9,173 individuals.

The effect Each copy of the A allele shifted the measure 0.361 lower; p = 1 × 10−26.

How common The A allele had a frequency of about 94% in the people studied.

Where it sits Chromosome 2, band 2q37.3 — in an intron of GAL3ST2.

What each result means

A/A Two copies of the version the research linked to Ovarian cancer-related tumor marker CA 125 levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Ovarian cancer-related tumor marker CA 125 levels. That is a smaller link than two copies.
G/G No copy of the version the research linked to Ovarian cancer-related tumor marker CA 125 levels. This is the starting point the study compared everyone against.
Source
Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals
Folkersen L, Gustafsson S, Wang Q, Hansen DH, Hedman ÅK, Schork A, Page K, Zhernakova DV, Wu Y, Peters J, Eriksson N, Bergen SE
and 71 more — show all
Boutin TS, Bretherick AD, Enroth S, Kalnapenkis A, Gådin JR, Suur BE, Chen Y, Matic L, Gale JD, Lee J, Zhang W, Quazi A, Ala-Korpela M, Choi SH, Claringbould A, Danesh J, Davey Smith G, de Masi F, Elmståhl S, Engström G, Fauman E, Fernandez C, Franke L, Franks PW, Giedraitis V, Haley C, Hamsten A, Ingason A, Johansson Å, Joshi PK, Lind L, Lindgren CM, Lubitz S, Palmer T, Macdonald-Dunlop E, Magnusson M, Melander O, Michaelsson K, Morris AP, Mägi R, Nagle MW, Nilsson PM, Nilsson J, Orho-Melander M, Polasek O, Prins B, Pålsson E, Qi T, Sjögren M, Sundström J, Surendran P, Võsa U, Werge T, Wernersson R, Westra HJ, Yang J, Zhernakova A, Ärnlöv J, Fu J, Smith JG, Esko T, Hayward C, Gyllensten U, Landen M, Siegbahn A, Wilson JF, Wallentin L, Butterworth AS, Holmes MV, Ingelsson E, Mälarstig A
Nature metabolism · 2020 · PMID 33067605

Questions about rs73011950

What is rs73011950?

rs73011950 is a single position in the genome, in or near the GAL3ST2 gene. Published research associates it with ovarian cancer-related tumor marker ca 125 levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs73011950 linked to?

On MyGeneLog this position is linked to Ovarian Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs73011950 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs73011950 come from?

GWAS Catalog, Nature metabolism 2020, PMID:33067605. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Ovarian cancer-related tumor marker CA 125 levels (rs73011950). MyGeneLog™. https://www.mygenelog.com/variants/rs73011950

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