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Uterine fibroids

POGLUT3 · rs72993806

Where this position leads

Condition: Uterine Fibroids

rs72993806 Condition: Uterine Fibroids Uterine Fibroids Condition rs72993806 rs72993806 POGLUT3

What the study found

Who was studied 20,406 European ancestry cases, 223,918 European ancestry controls; replicated in 15,068 European ancestry cases, 43,587 European ancestry controls.

The effect Each copy of the C allele shifted the measure 0.0895 higher (95% confidence interval 0.067-0.112); p = 5 × 10−15.

How common The C allele had a frequency of about 85% in the people studied.

Where it sits Chromosome 11, band 11q22.3 — in an intron of POGLUT3.

What each result means

C/C Two copies of the version the research linked to Uterine fibroids. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/G One copy of the version the research linked to Uterine fibroids. That is a smaller link than two copies.
G/G No copy of the version the research linked to Uterine fibroids. This is the starting point the study compared everyone against.
Source

Questions about rs72993806

What is rs72993806?

rs72993806 is a single position in the genome, in or near the POGLUT3 gene. Published research associates it with uterine fibroids. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs72993806 linked to?

On MyGeneLog this position is linked to Uterine Fibroids. The research behind each link, and its sources, are set out on that condition page.

Does having rs72993806 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs72993806 come from?

GWAS Catalog, Nature communications 2019, PMID:31649266. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Uterine fibroids (rs72993806). MyGeneLog™. https://www.mygenelog.com/variants/rs72993806

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