Standard

Triglycerides in large HDL

near C12orf42 · rs7298698

Where this position leads

Condition: Cholesterol (LDL, HDL and Total)

Strength of the evidence

2 / 4

Its strongest genetic-study result is p = 10⁻²⁸, with 14 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 241,027 British ancestry females.

The effect Each copy of the C allele shifted the measure 0.0284 mmol/L lower (95% confidence interval 0.023-0.034); p = 1 × 10⁻²⁶.

Where it sits Chromosome 12, band 12q23.2 — between genes, 24.7 kb from C12orf42-AS1.

How common each version is

CT

Korean KRGDB

C 83.1% · T 16.9%

Korean Korea4K

C 83.7% · T 16.3%

Korean Korea1K

C 84.9% · T 15.1%

Japanese ToMMo

C 74.4% · T 25.6%

Vietnamese

C 83.6% · T 16.4%

World gnomAD

C 56.9% · T 43.1%

World 1000 Genomes

C 64.3% · T 35.7%

World TOPMed

C 57.0% · T 43.0%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.

What each result means

C/C Two copies of the version the research linked to Triglycerides in large HDL. That is the strongest link of the three results. A link in a study is not a diagnosis.

C/T One copy of the version the research linked to Triglycerides in large HDL. That is a smaller link than two copies.

T/T No copy of the version the research linked to Triglycerides in large HDL. This is the starting point the study compared everyone against.

Source

A genetic map of human metabolism across the allele frequency spectrum

Zoodsma M, Beuchel C, Yasmeen S, Kohleick L, Nepal A, Koprulu M, Kronenberg F, Mayr M, Williamson A, Pietzner M, Langenberg C

Nature genetics · 2025 · PMID 41044249 · open access

Questions about rs7298698

What is rs7298698?

rs7298698 is a single position in the genome, in or near the near C12orf42 gene. Published research associates it with triglycerides in large hdl. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs7298698 linked to?

On MyGeneLog this position is linked to Cholesterol (LDL, HDL and Total). The research behind each link, and its sources, are set out on that condition page.

Does having rs7298698 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7298698 come from?

GWAS Catalog, Nature genetics 2025, PMID:41044249. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Triglycerides in large HDL (rs7298698). MyGeneLog™. https://www.mygenelog.com/variants/rs7298698

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