Sensitive

Large artery stroke

near MMP13 · rs72985562

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 213 African American cases, 20,030 African American controls, 1,735 East Asian ancestry cases, 237,242 East Asian ancestry controls, 6,399 European ancestry cases, 1,234,808 European ancestry controls, 167 Hispanic cases, 4,146 Hispanic controls, 705 South Asian ancestry cases, 7,672 South Asian ancestry controls.

The effect Each copy of the G allele carried 1.23 times the odds of Large artery stroke (95% confidence interval 1.14-1.33); p = 4 × 10⁻⁸.

How common The G allele had a frequency of about 8% in the people studied.

Where it sits Chromosome 11, band 11q22.2 — between genes, 13.4 kb from MMP13.

What each result means

G/G Two copies of the version the research linked to Large artery stroke. That is the strongest link of the three results. A link in a study is not a diagnosis.

G/T One copy of the version the research linked to Large artery stroke. That is a smaller link than two copies.

T/T No copy of the version the research linked to Large artery stroke. This is the starting point the study compared everyone against.

Source

Stroke genetics informs drug discovery and risk prediction across ancestries

Mishra A, Malik R, Hachiya T, Jürgenson T, Namba S, Posner DC, Kamanu FK, Koido M, Le Grand Q, Shi M, He Y, Georgakis MK

and 175 more — show all

Caro I, Krebs K, Liaw YC, Vaura FC, Lin K, Winsvold BS, Srinivasasainagendra V, Parodi L, Bae HJ, Chauhan G, Chong MR, Tomppo L, Akinyemi R, Roshchupkin GV, Habib N, Jee YH, Thomassen JQ, Abedi V, Cárcel-Márquez J, Nygaard M, Leonard HL, Yang C, Yonova-Doing E, Knol MJ, Lewis AJ, Judy RL, Ago T, Amouyel P, Armstrong ND, Bakker MK, Bartz TM, Bennett DA, Bis JC, Bordes C, Børte S, Cain A, Ridker PM, Cho K, Chen Z, Cruchaga C, Cole JW, de Jager PL, de Cid R, Endres M, Ferreira LE, Geerlings MI, Gasca NC, Gudnason V, Hata J, He J, Heath AK, Ho YL, Havulinna AS, Hopewell JC, Hyacinth HI, Inouye M, Jacob MA, Jeon CE, Jern C, Kamouchi M, Keene KL, Kitazono T, Kittner SJ, Konuma T, Kumar A, Lacaze P, Launer LJ, Lee KJ, Lepik K, Li J, Li L, Manichaikul A, Markus HS, Marston NA, Meitinger T, Mitchell BD, Montellano FA, Morisaki T, Mosley TH, Nalls MA, Nordestgaard BG, O'Donnell MJ, Okada Y, Onland-Moret NC, Ovbiagele B, Peters A, Psaty BM, Rich SS, Rosand J, Sabatine MS, Sacco RL, Saleheen D, Sandset EC, Salomaa V, Sargurupremraj M, Sasaki M, Satizabal CL, Schmidt CO, Shimizu A, Smith NL, Sloane KL, Sutoh Y, Sun YV, Tanno K, Tiedt S, Tatlisumak T, Torres-Aguila NP, Tiwari HK, Trégouët DA, Trompet S, Tuladhar AM, Tybjærg-Hansen A, van Vugt M, Vibo R, Verma SS, Wiggins KL, Wennberg P, Woo D, Wilson PWF, Xu H, Yang Q, Yoon K, Millwood IY, Gieger C, Ninomiya T, Grabe HJ, Jukema JW, Rissanen IL, Strbian D, Kim YJ, Chen PH, Mayerhofer E, Howson JMM, Irvin MR, Adams H, Wassertheil-Smoller S, Christensen K, Ikram MA, Rundek T, Worrall BB, Lathrop GM, Riaz M, Simonsick EM, Kõrv J, França PHC, Zand R, Prasad K, Frikke-Schmidt R, de Leeuw FE, Liman T, Haeusler KG, Ruigrok YM, Heuschmann PU, Longstreth WT, Jung KJ, Bastarache L, Paré G, Damrauer SM, Chasman DI, Rotter JI, Anderson CD, Zwart JA, Niiranen TJ, Fornage M, Liaw YP, Seshadri S, Fernández-Cadenas I, Walters RG, Ruff CT, Owolabi MO, Huffman JE, Milani L, Kamatani Y, Dichgans M, Debette S

COMPASS Consortium · INVENT Consortium · Dutch Parelsnoer Initiative (PSI) Cerebrovascular Disease Study Group · Estonian Biobank · PRECISE4Q Consortium · FinnGen Consortium · NINDS Stroke Genetics Network (SiGN) · MEGASTROKE Consortium · SIREN Consortium · China Kadoorie Biobank Collaborative Group · VA Million Veteran Program · International Stroke Genetics Consortium (ISGC) · Biobank Japan · CHARGE Consortium · GIGASTROKE Consortium

Nature · 2022 · PMID 36180795 · open access

Questions about rs72985562

What is rs72985562?

rs72985562 is a single position in the genome, in or near the near MMP13 gene. Published research associates it with large artery stroke. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs72985562 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs72985562 come from?

GWAS Catalog, Nature 2022, PMID:36180795. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Large artery stroke (rs72985562). MyGeneLog™. https://www.mygenelog.com/variants/rs72985562

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