Gene Knowledge Graph
UTC
Sensitive

Lacunar stroke

ICA1L · rs72934535

Where this position leads

Condition: Ischaemic Stroke

rs72934535 Condition: Ischaemic Stroke Ischaemic Stroke Condition rs72934535 rs72934535 ICA1L

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Lacunar stroke — no copies of the reported risk allele.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Lacunar stroke.
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Lacunar stroke compared to the general population.
Source
Genetic basis of lacunar stroke: a pooled analysis of individual patient data and genome-wide association studies
Traylor M, Persyn E, Tomppo L, Klasson S, Abedi V, Bakker MK, Torres N, Li L, Bell S, Rutten-Jacobs L, Tozer DJ, Griessenauer CJ
and 29 more — show all
Zhang Y, Pedersen A, Sharma P, Jimenez-Conde J, Rundek T, Grewal RP, Lindgren A, Meschia JF, Salomaa V, Havulinna A, Kourkoulis C, Crawford K, Marini S, Mitchell BD, Kittner SJ, Rosand J, Dichgans M, Jern C, Strbian D, Fernandez-Cadenas I, Zand R, Ruigrok Y, Rost N, Lemmens R, Rothwell PM, Anderson CD, Wardlaw J, Lewis CM, Markus HS
Helsinki Stroke, Study Dutch Parelsnoer Institute-Cerebrovascular Accident (CVA) Study Group · National Institute of Neurological Disorders and Stroke (NINDS) Stroke Genetics Network · UK DNA Lacunar Stroke Study Investigators · International Stroke Genetics Consortium
The Lancet. Neurology · 2021 · PMID 33773637 · open access

Questions about rs72934535

What is rs72934535?

rs72934535 is a single position in the genome, in or near the ICA1L gene. Published research associates it with lacunar stroke. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs72934535 linked to?

On MyGeneLog this position is linked to Ischaemic Stroke. The research behind each link, and its sources, are set out on that condition page.

Does having rs72934535 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs72934535 come from?

GWAS Catalog, Lancet Neurol 2021, PMID:33773637. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

← See all variants