Standard
Smoking initiation
RPS6KA4 · rs72926005
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 2,669,029 European ancestry individuals.
The effect
Each copy of the C allele shifted the measure 0.00867 lower (95% confidence interval 0.0068-0.0105); p = 3 × 10−20.
How common The C allele had a frequency of about 35% in the people studied.
Where it sits Chromosome 11, band 11q13.1 — in an intron of RPS6KA4.
What each result means
A/A
Published research associates this genotype with typical/baseline likelihood of Smoking initiation — no copies of the reported risk allele.
A/C
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Smoking initiation.
C/C
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Smoking initiation compared to the general population.
Source
Genetic diversity fuels gene discovery for tobacco and alcohol use
Saunders GRB,
Wang X,
Chen F,
Jang SK,
Liu M,
Wang C,
Gao S,
Jiang Y,
Khunsriraksakul C,
Otto JM,
Addison C,
Akiyama M
and 205 more — show all
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Tal-Singer R,
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Thai KK,
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Turman C,
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Nature · 2022 · PMID 36477530 · open access
Questions about rs72926005
What is rs72926005?
rs72926005 is a single position in the genome, in or near the RPS6KA4 gene. Published research associates it with smoking initiation. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs72926005 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs72926005 come from?
GWAS Catalog, Nature 2022, PMID:36477530. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Smoking initiation (rs72926005). MyGeneLog™. https://www.mygenelog.com/variants/rs72926005
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