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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 7,913 European, Hispanic or African American individuals; replicated in up to 2,466 African American individuals, up to 15,619 European ancestry individuals, 1,734 Hispanic ancestry children.
The effect
Each copy of the C allele shifted the measure 0.254 higher (95% confidence interval 0.22-0.29); p = 2 × 10−47.
How common The C allele had a frequency of about 28% in the people studied.
Where it sits Chromosome 11, band 11p15.5 — between genes, 12.3 kb from MIR4686.
What each result means
C/CTwo copies of the version the research linked to Metabolite levels (dopamine sulfate (2); dopamine 3-O-sulfate). That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Metabolite levels (dopamine sulfate (2); dopamine 3-O-sulfate). That is a smaller link than two copies.
T/TNo copy of the version the research linked to Metabolite levels (dopamine sulfate (2); dopamine 3-O-sulfate). This is the starting point the study compared everyone against.
Nature communications · 2023 · PMID 37253714 · open access
Questions about rs72853921
What is rs72853921?
rs72853921 is a single position in the genome, in or near the near MIR4686 gene. Published research associates it with metabolite levels (dopamine sulfate (2); dopamine 3-o-sulfate). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs72853921 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs72853921 come from?
GWAS Catalog, Nature communications 2023, PMID:37253714. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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