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Who was studied 1,275 Han Chinese ancestry cases, 2,100 Han Chinese ancestry controls; replicated in up to 1,720 East Asian ancestry cases, up to 132,885 East Asian ancestry controls.
The effect
Each copy of the C allele carried 1.56 times the odds of Type 1 diabetes (95% confidence interval 1.42-1.7); p = 2 × 10−14.
How common The C allele had a frequency of about 18% in the people studied.
Where it sits Chromosome 6, band 6p22.1 — in an intron of POLR1HASP.
What each result means
C/CTwo copies of the version the research linked to Type 1 diabetes. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Type 1 diabetes. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Type 1 diabetes. This is the starting point the study compared everyone against.
rs72848653 is a single position in the genome, in or near the POLR1HASP gene. Published research associates it with type 1 diabetes. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs72848653 linked to?
On MyGeneLog this position is linked to Type 1 Diabetes. The research behind each link, and its sources, are set out on that condition page.
Does having rs72848653 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs72848653 come from?
GWAS Catalog, Diabetologia 2025, PMID:40569436. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 5122Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot1Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others2Total5Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Type 1 diabetes (rs72848653). MyGeneLog™. https://www.mygenelog.com/variants/rs72848653