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Refractive error

BCAS3 · rs72843588

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10⁻⁹, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 1,495,159 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.0335 SD unit lower (95% confidence interval 0.022-0.045); p = 3 × 10⁻⁹.

How common The A allele had a frequency of about 2% in the people studied.

Where it sits Chromosome 17, band 17q23.2 — in an intron of BCAS3.

What each result means

A/A Two copies of the version the research linked to Refractive error. That is the strongest link of the three results. A link in a study is not a diagnosis.

A/G One copy of the version the research linked to Refractive error. That is a smaller link than two copies.

G/G No copy of the version the research linked to Refractive error. This is the starting point the study compared everyone against.

Source

Multi-ancestry genome-wide association analyses of refractive error augment genetic discovery and polygenic prediction

Cheng FF, Liu X, Mi H, Wang L, Ma R, Guo Y, Sidorenko J, Jiang C, Islam T, Meguro A, Hikino K, Ishikawa Y

and 15 more — show all

Tang S, Li T, Chen R, Wang L, Mägi R, Metspalu A, Takeuchi M, Mizuki N, Choquet H, Jin ZB, Chen G, Zhou K, Terao C, Zeng J, Yang J

Estonian Biobank Research Team · 23andMe Research Team

Nature genetics · 2026 · PMID 42009823 · open access

Questions about rs72843588

What is rs72843588?

rs72843588 is a single position in the genome, in or near the BCAS3 gene. Published research associates it with refractive error. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs72843588 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs72843588 come from?

GWAS Catalog, Nature genetics 2026, PMID:42009823. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Refractive error (rs72843588). MyGeneLog™. https://www.mygenelog.com/variants/rs72843588

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