Standard
Lung function (FEV1)
MICAL3 · rs7284335
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 475,645 European ancestry individuals, 8,590 African ancestry individuals, 85,279 East Asian ancestry individuals, 4,270 South Asian ancestry individuals, 14,668 Hispanic or Latin American individuals.
The effect
Each copy of the A allele shifted the measure 7.88 z score lower; p = 3 × 10−15.
How common The A allele had a frequency of about 23% in the people studied.
Where it sits Chromosome 22, band 22q11.21 — in an intron of MICAL3.
What each result means
A/A
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Lung function (FEV1) compared to the general population.
A/G
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Lung function (FEV1).
G/G
Published research associates this genotype with typical/baseline likelihood of Lung function (FEV1) — no copies of the reported risk allele.
Source
Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk
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Chen J,
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Malik V,
Hobbs BD,
Moll M
and 136 more — show all
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Nature genetics · 2023 · PMID 36914875 · open access
Questions about rs7284335
What is rs7284335?
rs7284335 is a single position in the genome, in or near the MICAL3 gene. Published research associates it with lung function (fev1). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs7284335 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs7284335 come from?
GWAS Catalog, Nature genetics 2023, PMID:36914875. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Lung function (FEV1) (rs7284335). MyGeneLog™. https://www.mygenelog.com/variants/rs7284335
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