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Who was studied 80,265 European and unknown ancestry cases, 305,011 European and unknown ancestry controls.
The effect
Each copy of the G allele carried 1.03 times the odds of Gastroesophageal reflux disease (95% confidence interval 1.02-1.05); p = 3 × 10−8.
Where it sits Chromosome 21, band 21q22.11 — in an intron of EPCIP-AS1.
What each result means
A/ANo copy of the version the research linked to Gastroesophageal reflux disease. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Gastroesophageal reflux disease. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Gastroesophageal reflux disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2019 · PMID 31527586 · open access
Questions about rs7282609
What is rs7282609?
rs7282609 is a single position in the genome, in or near the OLIG2 gene. Published research associates it with gastroesophageal reflux disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs7282609 linked to?
On MyGeneLog this position is linked to Gastroesophageal Reflux Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs7282609 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs7282609 come from?
GWAS Catalog, Nature communications 2019, PMID:31527586. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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