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Phospholipids to Total Lipids in Very Large VLDL percentage

near ADRB1 · rs72823016

Where this position leads

Condition: Cholesterol (LDL, HDL and Total)

rs72823016 Condition: Cholesterol (LDL, HDL and Total) Cholesterol (LDL, HDL and Total) Condition rs72823016 rs72823016 near ADRB1

Strength of the evidence

2 / 4

Its strongest genetic-study result is p = 10−20, with 2 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 434,646 British ancestry individuals, 8,796 British Central/South Asian individuals, 6,573 British African individuals.

The effect Each copy of the C allele shifted the measure 0.03 % higher (95% confidence interval 0.03-0.03); p = 1 × 10−20.

Where it sits Chromosome 10, band 10q25.3 — between genes, 15.5 kb from ADRB1.

What each result means

C/C Two copies of the version the research linked to Phospholipids to Total Lipids in Very Large VLDL percentage. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Phospholipids to Total Lipids in Very Large VLDL percentage. That is a smaller link than two copies.
T/T No copy of the version the research linked to Phospholipids to Total Lipids in Very Large VLDL percentage. This is the starting point the study compared everyone against.
Source

Questions about rs72823016

What is rs72823016?

rs72823016 is a single position in the genome, in or near the near ADRB1 gene. Published research associates it with phospholipids to total lipids in very large vldl percentage. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs72823016 linked to?

On MyGeneLog this position is linked to Cholesterol (LDL, HDL and Total). The research behind each link, and its sources, are set out on that condition page.

Does having rs72823016 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs72823016 come from?

GWAS Catalog, Nature genetics 2025, PMID:41044249. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Phospholipids to Total Lipids in Very Large VLDL percentage (rs72823016). MyGeneLog™. https://www.mygenelog.com/variants/rs72823016

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