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AFF3 · rs72819186
Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.
Strength of the evidence
Its strongest genetic-study result is p = 10−13, with 1 associations in the GWAS Catalog.
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied up to 53,293 European ancestry Attention-deficit/hyperactivity disorder individuals, up to 164,684 European ancestry problematic alcohol use individuals, up to 186,875 European ancestry lifetime cannabis use individuals, up to 357,187 European ancestry individuals measuring reverse-coded age at first sexual intercourse, up to 336,121 European ancestry individuals measuring number of sexual partners, up to 426,379 European ancestry individuals measuring general risk tolerance, up to 1,251,809 European ancestry individuals measuring lifetime smoking initiation.
The effect Each copy of the C allele shifted the measure 0.014 higher (95% confidence interval 0.01-0.018); p = 5 × 10−14.
How common The C allele had a frequency of about 88% in the people studied.
Where it sits Chromosome 2, band 2q11.2 — inside AFF3.
How common each version is
CT
C 100.0% · T 0.0%
C 91.8% · T 8.2%
C 97.1% · T 2.9%
C 93.4% · T 6.6%
The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.
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Externalizing behaviour (multivariate analysis) (rs72819186). MyGeneLog™. https://www.mygenelog.com/variants/rs72819186