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Metabolite levels (inosine; cmh_inosine; Inosine)

near DUTP5 · rs727870

What the study found

Who was studied 11,572 European, Hispanic or African American individuals; replicated in up to 2,466 African American individuals, up to 15,619 European ancestry individuals, 1,734 Hispanic ancestry children.

The effect Each copy of the G allele shifted the measure 0.154 higher (95% confidence interval 0.12-0.19); p = 6 × 10−17.

How common The G allele had a frequency of about 17% in the people studied.

Where it sits Chromosome 6, band 6q14.3 — between genes, 5.2 kb from DUTP5.

What each result means

A/A No copy of the version the research linked to Metabolite levels (inosine; cmh_inosine; Inosine). This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Metabolite levels (inosine; cmh_inosine; Inosine). That is a smaller link than two copies.
G/G Two copies of the version the research linked to Metabolite levels (inosine; cmh_inosine; Inosine). That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs727870

What is rs727870?

rs727870 is a single position in the genome, in or near the near DUTP5 gene. Published research associates it with metabolite levels (inosine; cmh_inosine; inosine). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs727870 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs727870 come from?

GWAS Catalog, Nature communications 2023, PMID:37253714. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Metabolite levels (inosine; cmh_inosine; Inosine) (rs727870). MyGeneLog™. https://www.mygenelog.com/variants/rs727870

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