MYH11 · rs72773978
Where this position leads
Condition: Multiple Myeloma
Strength of the evidence
Its strongest genetic-study result is p = 10−8, with 1 associations in the GWAS Catalog.
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 469 European ancestry cases, 25 African American cases, 27 Latino cases, 24 cases; replicated in 1090 European ancestry cases.
The effect Each copy of the T allele carried 1.93 times the odds of Multiple myeloma (survival) (95% confidence interval 1.54-2.41); p = 7 × 10−9.
How common The T allele had a frequency of about 5% in the people studied.
Where it sits Chromosome 16, band 16p13.11 — in an intron of CEP20.
How common each version is
AT
A 77.4% · T 22.6%
A 77.7% · T 22.3%
A 73.6% · T 26.4%
A 81.2% · T 18.8%
A 83.8% · T 16.2%
A 91.8% · T 8.2%
A 89.4% · T 10.6%
A 91.0% · T 9.0%
The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.
rs72773978 is a single position in the genome, in or near the MYH11 gene. Published research associates it with multiple myeloma (survival). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Multiple Myeloma. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nat Commun 2015, PMID:26198393. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Multiple myeloma (survival) (rs72773978). MyGeneLog™. https://www.mygenelog.com/variants/rs72773978