Standard
Cholesterol esters in very large HDL
near HNRNPCP4 · rs72771840
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.0404 lower (95% confidence interval 0.028-0.053); p = 2 × 10−10.
How common The A allele had a frequency of about 89% in the people studied.
Where it sits Chromosome 16, band 16p13.13 — between genes, 23 kb from HNRNPCP4.
What each result means
A/A
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Cholesterol esters in very large HDL compared to the general population.
A/G
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Cholesterol esters in very large HDL.
G/G
Published research associates this genotype with typical/baseline likelihood of Cholesterol esters in very large HDL — no copies of the reported risk allele.
Source
Genome-wide characterization of circulating metabolic biomarkers
Karjalainen MK,
Karthikeyan S,
Oliver-Williams C,
Sliz E,
Allara E,
Fung WT,
Surendran P,
Zhang W,
Jousilahti P,
Kristiansson K,
Salomaa V,
Goodwin M
and 75 more — show all
Hughes DA,
Boehnke M,
Fernandes Silva L,
Yin X,
Mahajan A,
Neville MJ,
van Zuydam NR,
de Mutsert R,
Li-Gao R,
Mook-Kanamori DO,
Demirkan A,
Liu J,
Noordam R,
Trompet S,
Chen Z,
Kartsonaki C,
Li L,
Lin K,
Hagenbeek FA,
Hottenga JJ,
Pool R,
Ikram MA,
van Meurs J,
Haller T,
Milaneschi Y,
Kähönen M,
Mishra PP,
Joshi PK,
Macdonald-Dunlop E,
Mangino M,
Zierer J,
Acar IE,
Hoyng CB,
Lechanteur YTE,
Franke L,
Kurilshikov A,
Zhernakova A,
Beekman M,
van den Akker EB,
Kolcic I,
Polasek O,
Rudan I,
Gieger C,
Waldenberger M,
Asselbergs FW,
Hayward C,
Fu J,
den Hollander AI,
Menni C,
Spector TD,
Wilson JF,
Lehtimäki T,
Raitakari OT,
Penninx BWJH,
Esko T,
Walters RG,
Jukema JW,
Sattar N,
Ghanbari M,
Willems van Dijk K,
Karpe F,
McCarthy MI,
Laakso M,
Järvelin MR,
Timpson NJ,
Perola M,
Kooner JS,
Chambers JC,
van Duijn C,
Slagboom PE,
Boomsma DI,
Danesh J,
Ala-Korpela M,
Butterworth AS,
Kettunen J
Nature · 2024 · PMID 38448586 · open access
Questions about rs72771840
What is rs72771840?
rs72771840 is a single position in the genome, in or near the near HNRNPCP4 gene. Published research associates it with cholesterol esters in very large hdl. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs72771840 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs72771840 come from?
GWAS Catalog, Nature 2024, PMID:38448586. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Cholesterol esters in very large HDL (rs72771840). MyGeneLog™. https://www.mygenelog.com/variants/rs72771840
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