Thyroid peroxidase antibody positivity in pregnancy
TIAM1 · rs7277015
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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 10,218 Chinese ancestry cases, 58,843 Chinese ancestry controls.
The effect
Each copy of the T allele carried 1.15 times the odds of Thyroid peroxidase antibody positivity in pregnancy (95% confidence interval 1.11-1.19); p = 5 × 10−13.
How common The T allele had a frequency of about 39% in the people studied.
Where it sits Chromosome 21, band 21q22.11 — in an intron of TIAM1.
What each result means
A/ANo copy of the version the research linked to Thyroid peroxidase antibody positivity in pregnancy. This is the starting point the study compared everyone against.
A/TOne copy of the version the research linked to Thyroid peroxidase antibody positivity in pregnancy. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Thyroid peroxidase antibody positivity in pregnancy. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2024 · PMID 39266554 · open access
Questions about rs7277015
What is rs7277015?
rs7277015 is a single position in the genome, in or near the TIAM1 gene. Published research associates it with thyroid peroxidase antibody positivity in pregnancy. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs7277015 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs7277015 come from?
GWAS Catalog, Nature communications 2024, PMID:39266554. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Thyroid peroxidase antibody positivity in pregnancy (rs7277015). MyGeneLog™. https://www.mygenelog.com/variants/rs7277015