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Sex hormone-binding globulin levels

NR2F2-AS1 · rs72769740

What the study found

Who was studied 310,323 European ancestry individuals, 5,523 African ancestry individuals, 6,638 South Asian ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.0519 higher (95% confidence interval 0.041-0.063); p = 3 × 10−20.

Where it sits Chromosome 15, band 15q26.2 — in an intron of NR2F2-AS1.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Sex hormone-binding globulin levels compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Sex hormone-binding globulin levels.
G/G Published research associates this genotype with typical/baseline likelihood of Sex hormone-binding globulin levels — no copies of the reported risk allele.
Source

Questions about rs72769740

What is rs72769740?

rs72769740 is a single position in the genome, in or near the NR2F2-AS1 gene. Published research associates it with sex hormone-binding globulin levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs72769740 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs72769740 come from?

GWAS Catalog, Nature genetics 2021, PMID:33462484. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Sex hormone-binding globulin levels (rs72769740). MyGeneLog™. https://www.mygenelog.com/variants/rs72769740

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