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Hip circumference adjusted for BMI

NPR3 · rs72740637

Where this position leads

Condition: Hip Circumference

rs72740637 Condition: Hip Circumference Hip Circumference Condition rs72740637 rs72740637 NPR3

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10−12, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 219,872 British ancestry women.

The effect Each copy of the A allele shifted the measure 0.0221 higher (95% confidence interval 0.016-0.028); p = 3 × 10−12.

Where it sits Chromosome 5, band 5p13.3 — in the 5′ untranslated region of NPR3.

What each result means

A/A Two copies of the version the research linked to Hip circumference adjusted for BMI. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Hip circumference adjusted for BMI. That is a smaller link than two copies.
G/G No copy of the version the research linked to Hip circumference adjusted for BMI. This is the starting point the study compared everyone against.
Source
GWAS of allometric body-shape indices in UK Biobank identifies loci suggesting associations with morphogenesis, organogenesis, adrenal cell renewal and cancer
Christakoudi S, Evangelou E, Riboli E, Tsilidis KK
Scientific reports · 2021 · PMID 34021172 · open access

Questions about rs72740637

What is rs72740637?

rs72740637 is a single position in the genome, in or near the NPR3 gene. Published research associates it with hip circumference adjusted for bmi. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs72740637 linked to?

On MyGeneLog this position is linked to Hip Circumference. The research behind each link, and its sources, are set out on that condition page.

Does having rs72740637 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs72740637 come from?

GWAS Catalog, Scientific reports 2021, PMID:34021172. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Hip circumference adjusted for BMI (rs72740637). MyGeneLog™. https://www.mygenelog.com/variants/rs72740637

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