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Orofacial clefts

CCDC26 · rs72728734

What the study found

Who was studied 576 European ancestry cases, 2,223 European ancestry controls.

The effect Each copy of the G allele carried 2.04 times the odds of Orofacial clefts (95% confidence interval 1.7-2.44); p = 7 × 10−15.

Where it sits Chromosome 8, band 8q24.21 — in an intron of CCDC26.

What each result means

A/A No copy of the version the research linked to Orofacial clefts. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Orofacial clefts. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Orofacial clefts. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs72728734

What is rs72728734?

rs72728734 is a single position in the genome, in or near the CCDC26 gene. Published research associates it with orofacial clefts. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs72728734 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs72728734 come from?

GWAS Catalog, Human molecular genetics 2016, PMID:27033726. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Orofacial clefts (rs72728734). MyGeneLog™. https://www.mygenelog.com/variants/rs72728734

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