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Who was studied 81,247 European ancestry individuals (MTAG effective sample size boosted by osteoarthritis, endometriosis and multiple sclerosis samples).
The effect
Each copy of the G allele shifted the measure 0.039 lower (95% confidence interval 0.029-0.049); p = 1 × 10−12.
How common The G allele had a frequency of about 26% in the people studied.
Where it sits Chromosome 15, band 15q14 — in an intron of RASGRP1.
What each result means
A/ANo copy of the version the research linked to Rheumatoid arthritis (MTAG). This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Rheumatoid arthritis (MTAG). That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Rheumatoid arthritis (MTAG). That is the strongest link of the three results. A link in a study is not a diagnosis.
Human reproduction (Oxford, England) · 2025 · PMID 40262193 · open access
Questions about rs72727387
What is rs72727387?
rs72727387 is a single position in the genome, in or near the RASGRP1 gene. Published research associates it with rheumatoid arthritis (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs72727387 linked to?
On MyGeneLog this position is linked to Rheumatoid Arthritis. The research behind each link, and its sources, are set out on that condition page.
Does having rs72727387 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs72727387 come from?
GWAS Catalog, Human reproduction (Oxford, England) 2025, PMID:40262193. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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