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IgG glycosylation patterns

near FUT8 · rs72712459

Where this position leads

Condition: IgG Glycosylation

rs72712459 Condition: IgG Glycosylation IgG Glycosylation Condition rs72712459 rs72712459 near FUT8

What the study found

Who was studied 1,823 European ancestry individuals; replicated in 1,836 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.257 lower (95% confidence interval 0.17-0.34); p = 1 × 10−9.

How common The A allele had a frequency of about 32% in the people studied.

Where it sits Chromosome 14, band 14q23.3 — between genes, 0.1 kb from RPL21P7.

What each result means

A/A Two copies of the version the research linked to IgG glycosylation patterns. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to IgG glycosylation patterns. That is a smaller link than two copies.
G/G No copy of the version the research linked to IgG glycosylation patterns. This is the starting point the study compared everyone against.
Source

Questions about rs72712459

What is rs72712459?

rs72712459 is a single position in the genome, in or near the near FUT8 gene. Published research associates it with igg glycosylation patterns. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs72712459 linked to?

On MyGeneLog this position is linked to IgG Glycosylation. The research behind each link, and its sources, are set out on that condition page.

Does having rs72712459 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs72712459 come from?

GWAS Catalog, Front Immunol 2018, PMID:29535710. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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IgG glycosylation patterns (rs72712459). MyGeneLog™. https://www.mygenelog.com/variants/rs72712459

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