Standard

Lactate levels

SLC24A3 · rs7269490

Where this position leads

Condition: Cholesterol (LDL, HDL and Total)

rs7269490 Condition: Cholesterol (LDL, HDL and Total) Cholesterol (LDL, HDL and Total) Condition rs7269490 rs7269490 SLC24A3

What the study found

Who was studied 434,646 British ancestry individuals, 8,796 British Central/South Asian individuals, 6,573 British African individuals.

The effect Each copy of the T allele shifted the measure 0.02 mmol/L higher (95% confidence interval 0.02-0.02); p = 1 × 10−12.

Where it sits Chromosome 20, band 20p11.23 — in an intron of SLC24A3.

What each result means

C/C No copy of the version the research linked to Lactate levels. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Lactate levels. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Lactate levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs7269490

What is rs7269490?

rs7269490 is a single position in the genome, in or near the SLC24A3 gene. Published research associates it with lactate levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs7269490 linked to?

On MyGeneLog this position is linked to Cholesterol (LDL, HDL and Total). The research behind each link, and its sources, are set out on that condition page.

Does having rs7269490 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7269490 come from?

GWAS Catalog, Nature genetics 2025, PMID:41044249. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Lactate levels (rs7269490). MyGeneLog™. https://www.mygenelog.com/variants/rs7269490

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