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Who was studied 47,745 European ancestry individuals.
The effect
Each copy of the C allele shifted the measure 0.0452 lower (95% confidence interval 0.032-0.059); p = 2 × 10−12.
How common The C allele had a frequency of about 16% in the people studied.
Where it sits Chromosome 4, band 4q24 — in an intron of TET2.
What each result means
A/ANo copy of the version the research linked to IL1RL2 protein levels. This is the starting point the study compared everyone against.
A/COne copy of the version the research linked to IL1RL2 protein levels. That is a smaller link than two copies.
C/CTwo copies of the version the research linked to IL1RL2 protein levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2025 · PMID 39789286 · open access
Questions about rs72665924
What is rs72665924?
rs72665924 is a single position in the genome, in or near the TET2 gene. Published research associates it with il1rl2 protein levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs72665924 linked to?
On MyGeneLog this position is linked to Celiac Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs72665924 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs72665924 come from?
GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
IL1RL2 protein levels (rs72665924). MyGeneLog™. https://www.mygenelog.com/variants/rs72665924