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Who was studied 24,167 European ancestry individuals; replicated in 9,456 European ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0 fl lower (95% confidence interval 0.002-0.004); p = 2 × 10−12.
Where it sits Chromosome 19, band 19p13.13 — inside HOOK2.
What each result means
A/ATwo copies of the version the research linked to Mean corpuscular volume. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Mean corpuscular volume. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Mean corpuscular volume. This is the starting point the study compared everyone against.
Nature genetics · 2009 · PMID 19862010 · open access
Questions about rs7255045
What is rs7255045?
rs7255045 is a single position in the genome, in or near the RTBDN gene. Published research associates it with mean corpuscular volume. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs7255045 linked to?
On MyGeneLog this position is linked to Blood Cell Counts. The research behind each link, and its sources, are set out on that condition page.
Does having rs7255045 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs7255045 come from?
GWAS Catalog, Nat Genet 2009, PMID:19862010. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
2 465216222125Reads by AI crawlersClaude5ChatGPT2Google · Gemini0Perplexity1Meta AI6Microsoft · Copilot2Amazon2Apple2China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others25Total46Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Mean corpuscular volume (rs7255045). MyGeneLog™. https://www.mygenelog.com/variants/rs7255045