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Chronic lymphocytic leukemia

ZBTB7A · rs7254272

Where this position leads

Condition: Chronic Lymphocytic Leukaemia

What the study found

Who was studied 4,478 European ancestry cases and 13,213 European ancestry controls.; replicated in 1,722 European ancestry cases and 4,385 European ancestry controls..

The effect Each copy of the A allele carried 1.17 times the odds of Chronic lymphocytic leukemia (95% confidence interval 1.10-1.23); p = 5 × 10⁻⁸.

How common The A allele had a frequency of about 18% in the people studied.

Where it sits Chromosome 19, band 19p13.3 — between genes, 1.5 kb from ZBTB7A.

What each result means

A/A Two copies of the version the research linked to Chronic lymphocytic leukemia. That is the strongest link of the three results. A link in a study is not a diagnosis.

A/G One copy of the version the research linked to Chronic lymphocytic leukemia. That is a smaller link than two copies.

G/G No copy of the version the research linked to Chronic lymphocytic leukemia. This is the starting point the study compared everyone against.

Source

Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia

Law PJ, Berndt SI, Speedy HE, Camp NJ, Sava GP, Skibola CF, Holroyd A, Joseph V, Sunter NJ, Nieters A, Bea S, Monnereau A

and 85 more — show all

Martin-Garcia D, Goldin LR, Clot G, Teras LR, Quintela I, Birmann BM, Jayne S, Cozen W, Majid A, Smedby KE, Lan Q, Dearden C, Brooks-Wilson AR, Hall AG, Purdue MP, Mainou-Fowler T, Vajdic CM, Jackson GH, Cocco P, Marr H, Zhang Y, Zheng T, Giles GG, Lawrence C, Call TG, Liebow M, Melbye M, Glimelius B, Mansouri L, Glenn M, Curtin K, Diver WR, Link BK, Conde L, Bracci PM, Holly EA, Jackson RD, Tinker LF, Benavente Y, Boffetta P, Brennan P, Maynadie M, McKay J, Albanes D, Weinstein S, Wang Z, Caporaso NE, Morton LM, Severson RK, Riboli E, Vineis P, Vermeulen RC, Southey MC, Milne RL, Clavel J, Topka S, Spinelli JJ, Kraft P, Ennas MG, Summerfield G, Ferri GM, Harris RJ, Miligi L, Pettitt AR, North KE, Allsup DJ, Fraumeni JF, Bailey JR, Offit K, Pratt G, Hjalgrim H, Pepper C, Chanock SJ, Fegan C, Rosenquist R, de Sanjose S, Carracedo A, Dyer MJ, Catovsky D, Campo E, Cerhan JR, Allan JM, Rothman N, Houlston R, Slager S

Nature communications · 2017 · PMID 28165464 · open access

Questions about rs7254272

What is rs7254272?

rs7254272 is a single position in the genome, in or near the ZBTB7A gene. Published research associates it with chronic lymphocytic leukemia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs7254272 linked to?

On MyGeneLog this position is linked to Chronic Lymphocytic Leukaemia. The research behind each link, and its sources, are set out on that condition page.

Does having rs7254272 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7254272 come from?

GWAS Catalog, Nat Commun 2017, PMID:28165464. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Chronic lymphocytic leukemia (rs7254272). MyGeneLog™. https://www.mygenelog.com/variants/rs7254272

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