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Sensitive

Peripheral artery disease

CYP2B7P · rs72480748

Where this position leads

Condition: Peripheral Artery Disease

rs72480748 Condition: Peripheral Artery Disease Peripheral Artery Disease Condition rs72480748 rs72480748 CYP2B7P

What the study found

Who was studied 2,784 Japanese ancestry male cases, 106,563 Japanese ancestry male controls.

The effect Each copy of the A allele carried 1.21 times the odds of Peripheral artery disease (95% confidence interval 1.131589307-1.297227288); p = 4 × 10−8.

How common The A allele had a frequency of about 24% in the people studied.

Where it sits Chromosome 19, band 19q13.2 — in a non-coding transcript of CYP2B7P.

What each result means

A/A Two copies of the version the research linked to Peripheral artery disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Peripheral artery disease. That is a smaller link than two copies.
G/G No copy of the version the research linked to Peripheral artery disease. This is the starting point the study compared everyone against.
Source
Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases
Ishigaki K, Akiyama M, Kanai M, Takahashi A, Kawakami E, Sugishita H, Sakaue S, Matoba N, Low SK, Okada Y, Terao C, Amariuta T
and 77 more — show all
Gazal S, Kochi Y, Horikoshi M, Suzuki K, Ito K, Koyama S, Ozaki K, Niida S, Sakata Y, Sakata Y, Kohno T, Shiraishi K, Momozawa Y, Hirata M, Matsuda K, Ikeda M, Iwata N, Ikegawa S, Kou I, Tanaka T, Nakagawa H, Suzuki A, Hirota T, Tamari M, Chayama K, Miki D, Mori M, Nagayama S, Daigo Y, Miki Y, Katagiri T, Ogawa O, Obara W, Ito H, Yoshida T, Imoto I, Takahashi T, Tanikawa C, Suzuki T, Sinozaki N, Minami S, Yamaguchi H, Asai S, Takahashi Y, Yamaji K, Takahashi K, Fujioka T, Takata R, Yanai H, Masumoto A, Koretsune Y, Kutsumi H, Higashiyama M, Murayama S, Minegishi N, Suzuki K, Tanno K, Shimizu A, Yamaji T, Iwasaki M, Sawada N, Uemura H, Tanaka K, Naito M, Sasaki M, Wakai K, Tsugane S, Yamamoto M, Yamamoto K, Murakami Y, Nakamura Y, Raychaudhuri S, Inazawa J, Yamauchi T, Kadowaki T, Kubo M, Kamatani Y
Nature genetics · 2020 · PMID 32514122

Questions about rs72480748

What is rs72480748?

rs72480748 is a single position in the genome, in or near the CYP2B7P gene. Published research associates it with peripheral artery disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs72480748 linked to?

On MyGeneLog this position is linked to Peripheral Artery Disease. The research behind each link, and its sources, are set out on that condition page.

Does having rs72480748 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs72480748 come from?

GWAS Catalog, Nature genetics 2020, PMID:32514122. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Peripheral artery disease (rs72480748). MyGeneLog™. https://www.mygenelog.com/variants/rs72480748

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