Standard
Heart rate response to beta blockers (atenolol add-on therapy)
MARCHF1 · rs723730
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What each result means
A/A
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Heart rate response to beta blockers (atenolol add-on therapy) compared to the general population.
A/T
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Heart rate response to beta blockers (atenolol add-on therapy).
T/T
Published research associates this genotype with typical/baseline likelihood of Heart rate response to beta blockers (atenolol add-on therapy) — no copies of the reported risk allele.
Source
Genome-Wide Association Approach Identified Novel Genetic Predictors of Heart Rate Response to β-Blockers
Shahin MH,
Conrado DJ,
Gonzalez D,
Gong Y,
Lobmeyer MT,
Beitelshees AL,
Boerwinkle E,
Gums JG,
Chapman A,
Turner ST,
Cooper-DeHoff RM,
Johnson JA
Journal of the American Heart Association · 2018 · PMID 29478026 · open access
Questions about rs723730
What is rs723730?
rs723730 is a single position in the genome, in or near the MARCHF1 gene. Published research associates it with heart rate response to beta blockers (atenolol add-on therapy). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs723730 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs723730 come from?
GWAS Catalog, J Am Heart Assoc 2018, PMID:29478026. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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