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Platelet distribution width (UKB data field 30110)

ZZEF1 · rs7225521

What the study found

Who was studied 394,642 European ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.0145 higher (95% confidence interval 0.011-0.018); p = 3 × 10−15.

How common The G allele had a frequency of about 53% in the people studied.

Where it sits Chromosome 17, band 17p13.2 — in an intron of ZZEF1.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Platelet distribution width (UKB data field 30110) — no copies of the reported risk allele.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Platelet distribution width (UKB data field 30110).
G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Platelet distribution width (UKB data field 30110) compared to the general population.
Source

Questions about rs7225521

What is rs7225521?

rs7225521 is a single position in the genome, in or near the ZZEF1 gene. Published research associates it with platelet distribution width (ukb data field 30110). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs7225521 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7225521 come from?

GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Platelet distribution width (UKB data field 30110) (rs7225521). MyGeneLog™. https://www.mygenelog.com/variants/rs7225521

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