B4GALNT2 · rs7224888
Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 11,369 European ancestry individuals, 400 African American individuals, 2,216 Hispanic individuals.
The effect Each copy of the T allele shifted the measure 0.252 lower (95% confidence interval 0.21-0.29); p = 2 × 10−32.
How common The T allele had a frequency of about 90% in the people studied.
Where it sits Chromosome 17, band 17q21.32 — a missense change in B4GALNT2.
What ClinVar records
Classification
Benign for BLOOD GROUP, SID SYSTEM; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 3 submitters), last evaluated 2020-02-17.
ClinVar record 1286620 NM_001159387.2(B4GALNT2):c.1216T>C (p.Cys406Arg)
What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
rs7224888 is a single position in the genome, in or near the B4GALNT2 gene. Published research associates it with serum uromodulin levels (antibody-based assay). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, JCI insight 2022, PMID:35446786. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Serum uromodulin levels (antibody-based assay) (rs7224888). MyGeneLog™. https://www.mygenelog.com/variants/rs7224888