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Who was studied 30,234 European ancestry cases, 724,172 European ancestry controls.
The effect
Each copy of the T allele carried 1.09 times the odds of Autoimmune thyroid disease; p = 4 × 10−10.
How common The T allele had a frequency of about 84% in the people studied.
Where it sits Chromosome 17, band 17p13.1 — in an intron of PIK3R5.
What each result means
G/GNo copy of the version the research linked to Autoimmune thyroid disease. This is the starting point the study compared everyone against.
G/TOne copy of the version the research linked to Autoimmune thyroid disease. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Autoimmune thyroid disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs7218886 is a single position in the genome, in or near the PIK3R5 gene. Published research associates it with autoimmune thyroid disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs7218886 linked to?
On MyGeneLog this position is linked to Autoimmune Thyroid Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs7218886 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs7218886 come from?
GWAS Catalog, Nature 2020, PMID:32581359. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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