SMG6 · rs7217226
Where this position leads
Conditions: Obesity and Body Weight, Waist-to-Hip Ratio (Body Fat Distribution)
Strength of the evidence
Its strongest genetic-study result is p = 10−15, with 7 associations in the GWAS Catalog.
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 374,756 European ancestry male individuals.
The effect Each copy of the T allele shifted the measure 0.0137 lower (95% confidence interval 0.01-0.017); p = 9 × 10−16.
How common The T allele had a frequency of about 66% in the people studied.
Where it sits Chromosome 17, band 17p13.3 — in an intron of LOC101927839.
How common each version is
GT
G 25.1% · T 74.9%
G 27.1% · T 73.0%
G 26.5% · T 73.5%
G 22.7% · T 77.3%
G 19.4% · T 80.6%
G 37.5% · T 62.5%
G 36.8% · T 63.2%
G 38.2% · T 61.8%
The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.
rs7217226 is a single position in the genome, in or near the SMG6 gene. Published research associates it with body mass index. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Obesity and Body Weight, Waist-to-Hip Ratio (Body Fat Distribution). The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Hum Mol Genet 2018, PMID:30239722. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Body mass index (rs7217226). MyGeneLog™. https://www.mygenelog.com/variants/rs7217226