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Who was studied 994 European ancestry cases, 1,243 European ancestry controls; replicated in 200 European ancestry cases, 2,120 European ancestry controls.
The effect
Each copy of the T allele carried 1.45 times the odds of Asthma (95% confidence interval 1.17-1.81); p = 9 × 10−11.
How common The T allele had a frequency of about 52% in the people studied.
Where it sits Chromosome 17, band 17q21.1 — in an intron of GSDMB.
What each result means
C/CNo copy of the version the research linked to Asthma. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Asthma. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Asthma. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs7216389 is a single position in the genome, in or near the ORMDL3 gene. Published research associates it with asthma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs7216389 linked to?
On MyGeneLog this position is linked to Asthma. The research behind each link, and its sources, are set out on that condition page.
Does having rs7216389 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs7216389 come from?
GWAS Catalog, Nature 2007, PMID:17611496. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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