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White matter hyperintensity burden

TRIM65 · rs7214628

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 17,936 European ancestry individuals, 1,943 African American ancestry individuals, 795 Hispanic individuals, 204 Chinese ancestry individuals, 201 Malay ancestry individuals.

The effect The reported allele is G; the catalogue records no effect size ; p = 3 × 10⁻¹⁹.

How common The G allele had a frequency of about 19% in the people studied.

Where it sits Chromosome 17, band 17q25.1 — inside TRIM65.

What each result means

A/A No copy of the version the research linked to White matter hyperintensity burden. This is the starting point the study compared everyone against.

A/G One copy of the version the research linked to White matter hyperintensity burden. That is a smaller link than two copies.

G/G Two copies of the version the research linked to White matter hyperintensity burden. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Multiethnic genome-wide association study of cerebral white matter hyperintensities on MRI

Verhaaren BF, Debette S, Bis JC, Smith JA, Ikram MK, Adams HH, Beecham AH, Rajan KB, Lopez LM, Barral S, van Buchem MA, van der Grond J

and 90 more — show all

Smith AV, Hegenscheid K, Aggarwal NT, de Andrade M, Atkinson EJ, Beekman M, Beiser AS, Blanton SH, Boerwinkle E, Brickman AM, Bryan RN, Chauhan G, Chen CP, Chouraki V, de Craen AJ, Crivello F, Deary IJ, Deelen J, De Jager PL, Dufouil C, Elkind MS, Evans DA, Freudenberger P, Gottesman RF, Guðnason V, Habes M, Heckbert SR, Heiss G, Hilal S, Hofer E, Hofman A, Ibrahim-Verbaas CA, Knopman DS, Lewis CE, Liao J, Liewald DC, Luciano M, van der Lugt A, Martinez OO, Mayeux R, Mazoyer B, Nalls M, Nauck M, Niessen WJ, Oostra BA, Psaty BM, Rice KM, Rotter JI, von Sarnowski B, Schmidt H, Schreiner PJ, Schuur M, Sidney SS, Sigurdsson S, Slagboom PE, Stott DJ, van Swieten JC, Teumer A, Töglhofer AM, Traylor M, Trompet S, Turner ST, Tzourio C, Uh HW, Uitterlinden AG, Vernooij MW, Wang JJ, Wong TY, Wardlaw JM, Windham BG, Wittfeld K, Wolf C, Wright CB, Yang Q, Zhao W, Zijdenbos A, Jukema JW, Sacco RL, Kardia SL, Amouyel P, Mosley TH, Longstreth WT Jr, DeCarli CC, van Duijn CM, Schmidt R, Launer LJ, Grabe HJ, Seshadri SS, Ikram MA, Fornage M

Circulation. Cardiovascular genetics · 2015 · PMID 25663218

Questions about rs7214628

What is rs7214628?

rs7214628 is a single position in the genome, in or near the TRIM65 gene. Published research associates it with white matter hyperintensity burden. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs7214628 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7214628 come from?

GWAS Catalog, Circulation. Cardiovascular genetics 2015, PMID:25663218. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

White matter hyperintensity burden (rs7214628). MyGeneLog™. https://www.mygenelog.com/variants/rs7214628

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