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Who was studied 23,021 European ancestry cases, 296,016 European ancestry controls.
The effect
Each copy of the A allele carried 0.91 times the odds of Osteoarthritis (with total hip replacement) (95% confidence interval 0.886261257-0.935890777); p = 2 × 10−11.
How common The A allele had a frequency of about 80% in the people studied.
Where it sits Chromosome 17, band 17q23.2 — between genes, 13.2 kb from NACA2.
What each result means
A/ATwo copies of the version the research linked to Osteoarthritis (with total hip replacement). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Osteoarthritis (with total hip replacement). That is a smaller link than two copies.
G/GNo copy of the version the research linked to Osteoarthritis (with total hip replacement). This is the starting point the study compared everyone against.
rs7212908 is a single position in the genome, in or near the near NACA2 gene. Published research associates it with osteoarthritis (with total hip replacement). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs7212908 linked to?
On MyGeneLog this position is linked to Osteoarthritis. The research behind each link, and its sources, are set out on that condition page.
Does having rs7212908 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs7212908 come from?
GWAS Catalog, Cell 2021, PMID:34450027. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 22Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon0Apple0China (ByteDance, Huawei, Baidu…)0Others2Total2Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Osteoarthritis (with total hip replacement) (rs7212908). MyGeneLog™. https://www.mygenelog.com/variants/rs7212908