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Thyroid stimulating hormone levels

MAFTRR · rs7203756

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 247,107 European ancestry individuals; replicated in 63,326 European ancestry individuals, 33,171 South Asian ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.0883 higher (95% confidence interval 0.083-0.094); p = 3 × 10−228.

How common The A allele had a frequency of about 68% in the people studied.

Where it sits Chromosome 16, band 16q23.2 — in an intron of MAFTRR.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Thyroid stimulating hormone levels compared to the general population.
A/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Thyroid stimulating hormone levels.
T/T Published research associates this genotype with typical/baseline likelihood of Thyroid stimulating hormone levels — no copies of the reported risk allele.
Source
Genome-wide association study of thyroid-stimulating hormone highlights new genes, pathways and associations with thyroid disease
Williams AT, Chen J, Coley K, Batini C, Izquierdo A, Packer R, Abner E, Kanoni S, Shepherd DJ, Free RC, Hollox EJ, Brunskill NJ
and 20 more — show all
Ntalla I, Reeve N, Brightling CE, Venn L, Adams E, Bee C, Wallace SE, Pareek M, Hansell AL, Esko T, Stow D, Jacobs BM, van Heel DA, Hennah W, Rao BS, Dudbridge F, Wain LV, Shrine N, Tobin MD, John C
Estonian Biobank Research Team · Genes & Health Research Team
Nature communications · 2023 · PMID 37872160 · open access

Questions about rs7203756

What is rs7203756?

rs7203756 is a single position in the genome, in or near the MAFTRR gene. Published research associates it with thyroid stimulating hormone levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs7203756 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7203756 come from?

GWAS Catalog, Nature communications 2023, PMID:37872160. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Thyroid stimulating hormone levels (rs7203756). MyGeneLog™. https://www.mygenelog.com/variants/rs7203756

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