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Reticulocyte count

HBZP1 · rs7194649

Where this position leads

Condition: Blood Cell Counts

rs7194649 Condition: Blood Cell Counts Blood Cell Counts Condition rs7194649 rs7194649 HBZP1

What the study found

Who was studied 170,641 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.0641 lower (95% confidence interval 0.052-0.076); p = 9 × 10−27.

How common The A allele had a frequency of about 11% in the people studied.

Where it sits Chromosome 16, band 16p13.3 — in a non-coding transcript of HBZP1.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Reticulocyte count compared to the general population.
A/C Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Reticulocyte count.
C/C Published research associates this genotype with typical/baseline likelihood of Reticulocyte count — no copies of the reported risk allele.
Source

Questions about rs7194649

What is rs7194649?

rs7194649 is a single position in the genome, in or near the HBZP1 gene. Published research associates it with reticulocyte count. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs7194649 linked to?

On MyGeneLog this position is linked to Blood Cell Counts. The research behind each link, and its sources, are set out on that condition page.

Does having rs7194649 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7194649 come from?

GWAS Catalog, Cell 2016, PMID:27863252. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Reticulocyte count (rs7194649). MyGeneLog™. https://www.mygenelog.com/variants/rs7194649

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