Sensitive

Alzheimer's disease (late onset)

IQCK · rs7185636

Where this position leads

Condition: Alzheimer's Disease

rs7185636 Condition: Alzheimer's Disease Alzheimer's Disease Condition rs7185636 rs7185636 IQCK

What the study found

Who was studied 21,982 European ancestry cases, 41,944 European ancestry controls; replicated in up to 13,292 European ancestry cases, up to 17,219 European ancestry controls.

The effect Each copy of the T allele carried 1.09 times the odds of Alzheimer's disease (late onset) (95% confidence interval 1.05-1.12); p = 2 × 10−8.

How common The T allele had a frequency of about 82% in the people studied.

Where it sits Chromosome 16, band 16p12.3 — in an intron of IQCK.

What each result means

C/C No copy of the version the research linked to Alzheimer's disease (late onset). This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Alzheimer's disease (late onset). That is a smaller link than two copies.
T/T Two copies of the version the research linked to Alzheimer's disease (late onset). That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs7185636

What is rs7185636?

rs7185636 is a single position in the genome, in or near the IQCK gene. Published research associates it with alzheimer's disease (late onset). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs7185636 linked to?

On MyGeneLog this position is linked to Alzheimer's Disease. The research behind each link, and its sources, are set out on that condition page.

Does having rs7185636 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7185636 come from?

GWAS Catalog, Nature genetics 2019, PMID:30820047. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Alzheimer's disease (late onset) (rs7185636). MyGeneLog™. https://www.mygenelog.com/variants/rs7185636

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