Gene Knowledge Graph
UTC
Standard

Psoriasis

PDE8A · rs7171410

Where this position leads

Condition: Psoriasis

rs7171410 Condition: Psoriasis Psoriasis Condition rs7171410 rs7171410 PDE8A

What the study found

Who was studied 36,466 European ancestry cases, 458,078 European ancestry controls.

The effect Each copy of the A allele carried 1.05 times the odds of Psoriasis (95% confidence interval 1.04-1.07); p = 4 × 10−8.

Where it sits Chromosome 15, band 15q25.3 — in an intron of PDE8A.

What each result means

A/A Two copies of the version the research linked to Psoriasis. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Psoriasis. That is a smaller link than two copies.
G/G No copy of the version the research linked to Psoriasis. This is the starting point the study compared everyone against.
Source
GWAS meta-analysis of psoriasis identifies new susceptibility alleles impacting disease mechanisms and therapeutic targets
Dand N, Stuart PE, Bowes J, Ellinghaus D, Nititham J, Saklatvala JR, Teder-Laving M, Thomas LF, Traks T, Uebe S, Assmann G, Baudry D
and 73 more — show all
Behrens F, Billi AC, Brown MA, Burkhardt H, Capon F, Chung R, Curtis CJ, Duckworth M, Ellinghaus E, FitzGerald O, Gerdes S, Griffiths CEM, Gulliver S, Helliwell PS, Ho P, Hoffmann P, Holmen OL, Huang ZM, Hveem K, Jadon D, Köhm M, Kraus C, Lamacchia C, Lee SH, Ma F, Mahil SK, McHugh N, McManus R, Modalsli EH, Nissen MJ, Nöthen M, Oji V, Oksenberg JR, Patrick MT, Perez White BE, Ramming A, Rech J, Rosen C, Sarkar MK, Schett G, Schmidt B, Tejasvi T, Traupe H, Voorhees JJ, Wacker EM, Warren RB, Wasikowski R, Weidinger S, Wen X, Zhang Z, Barton A, Chandran V, Esko T, Foerster J, Franke A, Gladman DD, Gudjonsson JE, Gulliver W, Hüffmeier U, Kingo K, Kõks S, Liao W, Løset M, Mägi R, Nair RP, Rahman P, Reis A, Smith CH, Di Meglio P, Barker JN, Tsoi LC, Simpson MA, Elder JT
BSTOP study group · Estonian Biobank research team
Nature communications · 2025 · PMID 40021644 · open access

Questions about rs7171410

What is rs7171410?

rs7171410 is a single position in the genome, in or near the PDE8A gene. Published research associates it with psoriasis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs7171410 linked to?

On MyGeneLog this position is linked to Psoriasis. The research behind each link, and its sources, are set out on that condition page.

Does having rs7171410 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7171410 come from?

GWAS Catalog, Nature communications 2025, PMID:40021644. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Psoriasis (rs7171410). MyGeneLog™. https://www.mygenelog.com/variants/rs7171410

← See all variants