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Who was studied 58,783 European ancestry cases, 633,203 European ancestry controls.
The effect
Each copy of the T allele carried 1.10 times the odds of Hypothyroidism (95% confidence interval 1.07-1.13); p = 2 × 10−10.
Where it sits Chromosome 7, band 7q32.1 — in an intron of TNPO3.
What each result means
C/CNo copy of the version the research linked to Hypothyroidism. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Hypothyroidism. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Hypothyroidism. That is the strongest link of the three results. A link in a study is not a diagnosis.
European journal of endocrinology · 2024 · PMID 39067062
Questions about rs71581958
What is rs71581958?
rs71581958 is a single position in the genome, in or near the TNPO3 gene. Published research associates it with hypothyroidism. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs71581958 linked to?
On MyGeneLog this position is linked to Hypothyroidism. The research behind each link, and its sources, are set out on that condition page.
Does having rs71581958 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs71581958 come from?
GWAS Catalog, European journal of endocrinology 2024, PMID:39067062. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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