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Diffuse large B-cell lymphoma

near ZNF322 · rs71557353

Where this position leads

Condition: Diffuse Large B Cell Lymphoma

rs71557353 Condition: Diffuse Large B Cell Lymphoma Diffuse Large B Cell Lymphoma Condition rs71557353 rs71557353 near ZNF322

What the study found

Who was studied 2,280 European ancestry cases, 656,255 European ancestry controls.

The effect Each copy of the G allele carried 1.28 times the odds of Diffuse large B-cell lymphoma (95% confidence interval 1.17-1.39); p = 3 × 10−8.

How common The G allele had a frequency of about 15% in the people studied.

Where it sits Chromosome 6, band 6p22.2 — between genes, 5.5 kb from GUSBP2.

What each result means

G/G Two copies of the version the research linked to Diffuse large B-cell lymphoma. That is the strongest link of the three results. A link in a study is not a diagnosis.
G/T One copy of the version the research linked to Diffuse large B-cell lymphoma. That is a smaller link than two copies.
T/T No copy of the version the research linked to Diffuse large B-cell lymphoma. This is the starting point the study compared everyone against.
Source

Questions about rs71557353

What is rs71557353?

rs71557353 is a single position in the genome, in or near the near ZNF322 gene. Published research associates it with diffuse large b-cell lymphoma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs71557353 linked to?

On MyGeneLog this position is linked to Diffuse Large B Cell Lymphoma. The research behind each link, and its sources, are set out on that condition page.

Does having rs71557353 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs71557353 come from?

GWAS Catalog, Blood cancer journal 2025, PMID:40883272. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Diffuse large B-cell lymphoma (rs71557353). MyGeneLog™. https://www.mygenelog.com/variants/rs71557353

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